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| 儿童系统性红斑狼疮与HLA-DPB1基因相关性研究 | |
| 引用本文： | 张俊梅,李彩凤,何晓琥. 儿童系统性红斑狼疮与HLA-DPB1基因相关性研究[J]. 北京医学, 2010, 32(11): 910-913 |
| 作者姓名： | 张俊梅 李彩凤 何晓琥 |
| 作者单位： | 首都医科大学附属北京儿童医院内科,100045;首都医科大学附属北京儿童医院内科,100045;首都医科大学附属北京儿童医院内科,100045 |
| 摘 要： | 目的研究儿童系统性红斑狼疮（SLE）与人类白细胞抗原（HLA）-DPB1基因的相关性。方法对95例SLE患儿和74例正常对照者,应用序列特异性引物聚合酶链式反应扩增法（PCR-SSP）检测HLA-DPB1基因的等位基因。结果 DPB1＊0501等位基因频率在SLE组（31.6%）明显低于对照组（48.0%）,校正P值（Pc）〈0.05,相对风险度（RR）为0.4792,预防分数（PF）为0.3730。DPB1＊0201等位基因频率在狼疮脑病患儿明显高于正常对照组;DPB1＊0501等位基因频率在狼疮脑病患儿明显低于正常对照组,但确切概率P值（Pf）〉0.05;其余各等位基因频率在SLE组和对照组、SLE不同临床表型与对照组间均无显著性差异（Pf〉0.05）。结论 DPB1＊0501等位基因可能对儿童系统性红斑狼疮发病有保护性作用。 |
| 关 键 词： | 系统性红斑狼疮 HLA-DPB1基因 |
A study on the association of HLA-DPB1 gene with childhood systemic lupus erythematosus |
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| ZHANG Jun-mei,LI Cai-feng,HE Xiao-hu. A study on the association of HLA-DPB1 gene with childhood systemic lupus erythematosus[J]. Beijing Medical Journal, 2010, 32(11): 910-913 | |
| Authors: | ZHANG Jun-mei LI Cai-feng HE Xiao-hu |
| Affiliation: | ZHANG Jun-mei,LI Cai-feng,HE Xiao-hu (Department of Internal,Beijing Children's Hospital,Beijing 100045) |
| Abstract: | Objective To study the association of HLA-DPB1 gene with childhood systemic lupus erythematosus (SLE). Methods DPB1 gene was genotyped by polymerase chain reaction-sequence specific primers (PCR-SSP) in 95 patients with SLE and 74 normal controls. Results The frequency of DPB1*0501 was significantly lower in SLE patients (31.6%)than in the controls(48.0%, Pc < 0.05), RR was 0.4792, PF was 0.3730. The frequency of DPB1*0201 was higher in SLE patients with central nervous system involvement (44.4% ) than in t... |
| Keywords: | Systemic lupus erythematosus(SLE) HLA-DPB1 gene |
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