| 遗传性非息肉病性大肠癌(10个家族27例报告) |
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| 引用本文： | 陈钢.遗传性非息肉病性大肠癌(10个家族27例报告)[J].中国肿瘤临床,2003,30(4):247-249. |
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| 作者姓名： | 陈钢 |
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| 作者单位： | 天津市滨江医院肛肠科,天津市,300041 |
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| 摘 要： | 分析遗传性非息肉病性大肠癌(HNPCC)的临床特点。方法:对10个家族27例HNPCC患者(A组)进行回顾性分析,并设30例一般大肠癌为对照组(B组)进行比较。结果:<50岁患者A组占59.3%(16/27),B组占23.3%(7/30),P<0.05。脾曲以上癌灶A组为40.0%(12/30),B组为16.1%(5/31),P<0.05。大肠多原发癌A组占10.0%(3/30),B组占3.2%(1/31)。大肠外肿瘤A组6例,B组2例。结论:HNPCC具有典型的临床特征,这些特征可以对HNPCC患者进行早期诊断及治疗,以得到较好的预后。
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| 关 键 词： | 大肠癌 遗传性 非息肉性 临床特征 诊断 治疗 |
| 文章编号： | 1000-8179(2003)04-0247-03 |
| 修稿时间： | 2002年7月8日 |
Hereditary Nonpolyposis Colorectal Cancer:A Report of 27 Cases in 10 Families |
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| Chen Gang.Hereditary Nonpolyposis Colorectal Cancer:A Report of 27 Cases in 10 Families[J].Chinese Journal of Clinical Oncology,2003,30(4):247-249. |
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| Authors: | Chen Gang |
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| Institution: | Chen Gang Department of Anorectal Surgery,Tianjin Binjiang Hospital,Tianjin China |
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| Abstract: | Objective:To analyse the clinical features of hereditary nonpolyposis colorectal cancer(HNPCC).Methods:A retrospective analysis of27HNPCC cases in10families(group A)was made and compare with30general colorectal cancer cases(group B).Results:Patients under the age of50were significantly higher in group A59.3%(16/27)than in group B23.3%(7/30)P<0.05.The tumors were found perximally to splenic flexure colon40%(12/30)in group A and16.1%(5/31)in group B P<0.05.Multiple primary colorectal cancer had10%(3/30)in group A and3.2%(1/31)in group B.Pafients who suffered from cancer in other organs had6cases in group A and2cases in group B.Conclusion:HNPCC has typical clinical features,ac-cording to these features,We can make the diagnosis and treatment at the ealy stage and get a better prognosis. |
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| Keywords: | Colorectal cancer Hereditary nonpolyposis Clinical feature |
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