抗脑部肿瘤纳米药物的研究进展

恶性脑部肿瘤严重威胁着人类生命健康。尽管目前医疗水平与治疗技术均取得了进步，但大多数脑瘤患者的预后仍较差。保护性血脑屏障（blood brain barrier, BBB）的存在会阻碍药物的有效输送，导致治疗效果不佳。伴随纳米技术的突破，能够穿越BBB的多功能纳米药物应运而生，使治疗药物得以有效递送至脑部病灶。综述可克服BBB的纳米药物设计策略，可穿越BBB纳米药物在脑部肿瘤治疗中的最新进展，总结当前纳米药物用于脑部肿瘤治疗中存在的问题和解决策略，旨在为抗脑部肿瘤纳米药物的开发提供参考。

Advances in Nanomedicines for Brain Tumor Treatments

Malignant brain tumors seriously threaten human health.Despite the great progress in medical treatment with better clinical technology, the prognosis for most brain cancer patients still remains poor.The protective blood brain barrier (BBB) blocks the effective delivery of drugs, leading to the treatment failure of various drugs.Recent breakthroughs in nanotechnology have endowed multifunctional nanomedicines with the ability to cross the BBB, enabling accumulation of therapeutic drugs in brain tumors.This review discusses the design strategies of BBB-crossing nanomedicines and their current progress in brain tumor treatment, and summarizes the existing problems of nanomedicines for brain tumor treatment as well as the potential strategies to overcome these limitations, so as to provide reference for developing nanomedicines for brain tumor treatment.