虾青素对创伤性颅脑损伤保护作用的研究进展

创伤性颅脑损伤（TBI）致死、致残率高，严重危害人类健康，TBI后的继发级联损伤是导致患者预后不良的重要原因。有效地治疗继发性脑损伤是降低TBI致残率，改善患者预后，提高生活质量的重要环节。虾青素（ATX）是一种天然的类胡萝卜素，具有多种生物学活性。许多研究表明了ATX在对抗中枢神经系统急慢性损伤中产生的氧化应激、炎症反应以及改善颅脑灌注、保护神经等方面有良好作用。本文针对ATX对TBI的保护作用机制及研究进展综述如下。

Research progress on the protective effect of astaxanthin on traumatic brain injury

Traumatic brain injury (TBI) is fatal and has a high disability rate, which is a serious hazard to human health. Secondary cascading injury after TBI is an important cause of poor prognosis. Effective treatment of secondary brain injury is an important part of reducing TBI disability, improving patient prognosis and improving quality of life. Astaxanthin (ATX) is a natural carotenoid with a variety of biological activities. Many studies have shown that ATX has a good effect on fighting acute and chronic damage of the central nervous system, oxidative stress, inflammatory response, improving perfusion, and protecting nerves. The protective mechanism and research progress of ATX on TBI are summarized as follows.