Comparative Sequence Analyses of La Crosse Virus Strain Isolated from Patient with Fatal Encephalitis,Tennessee, USA |
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| Authors: | Amy J. Lambert Rebecca Trout Fryxell Kimberly Freyman Armando Ulloa Jason O. Velez Dave Paulsen Robert S. Lanciotti Abelardo Moncayo |
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| Affiliation: | Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (A.J. Lambert, J.O. Velez, R.S. Lanciotti); ;University of Tennessee, Knoxville, Tennessee, USA (R.T. Fryxell, D. Paulsen); ;Tennessee Department of Health, Nashville, Tennessee, USA (K. Freyman, A. Ulloa, A. Moncayo) |
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| Abstract: | We characterized a La Crosse virus (LACV) isolate from the brain of a child who died of encephalitis-associated complications in eastern Tennessee, USA, during summer 2012. We compared the isolate with LACV sequences from mosquitoes collected near the child’s home just after his postmortem diagnosis. In addition, we conducted phylogenetic analyses of these and other sequences derived from LACV strains representing varied temporal, geographic, and ecologic origins. Consistent with historical findings, results of these analyses indicate that a limited range of LACV lineage I genotypes is associated with severe clinical outcomes. |
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| Keywords: | La Crosse virus viruses sequence Tennessee children vector-borne infections mosquitoes encephalitis United States |
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