黑龙江24 597例宫颈癌筛查女性HPV分型检测结果分析

目的分析黑龙江省女性人乳头瘤状病毒(human papillomavirus,HPV)感染现状,为宫颈癌的防治提供一定的参考依据。 方法收集2018年1月至10月24 597例送检的HPV病毒检测宫颈脱落细胞筛查标本,采用PCR反向点杂交法共检测23种型别。 结果HPV阳性率为32.16%,其中高危型别阳性率占总阳性率的77.33%,单一型别感染率和多重型别感染率存在极显著差异(P<0.01);根据年龄由低到高共分为6组,其阳性率呈"U"形曲线,感染率排在前五位的型别为16型、52型、58型、53型、51型,感染率分别为5.04%、4.34%、3.00%、2.92%、2.31%。 结论女性HPV感染率以高危型别为主,且与年龄关系密切,30岁以下及50岁以上的女性感染率明显较高,该研究为HPV的检测以及宫颈癌的筛查提供一定的参考依据。

Analysis of HPV typing results in 24 597 women screened for cervical cancer in Heilongjiang Province

ObjectiveTo analyze human papillomavirus (HPV) infection in Heilongjiang Province so as to provide some reference for the prevention and treatment of cervical cancer. MethodsA total of 23 types of HPV were detected by reverse dot hybridization (RPH) with polymerase chain reaction (PCR) from 24 597 female cervical exfoliated cell specimens collected during January 2018 to October 2018. ResultsThe positive rate of HPV was 32.16%, among which the high-risk typeaccounted for 77.33%. There were significant differences among single type infection rate and multiple type infection rate (P<0.01). According to age, HPV was divided into six groups, and the positive rate was U-shaped curve. The top five types with higher infection rate were type 16, 52, 58, 53, 51, and the infection rate were 5.04%, 3.34%, 3.00%, 2.92% and 2.31% respectively. ConclusionsHPV infection in women is mainly high-risk type, which is closely related to age. The infection rate of women under 30 years old and over 50 years old is significantly higher. This study provides some reference for the HPV detection and cervical cancer screening.