| 新型抗生素在耐药鲍曼不动杆菌感染治疗中的研究进展 |
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| 引用本文： | 陈佳浩,李国才. 新型抗生素在耐药鲍曼不动杆菌感染治疗中的研究进展[J]. 中国新药与临床杂志, 2020, 0(4): 198-203 |
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| 作者姓名： | 陈佳浩 李国才 |
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| 作者单位： | 扬州大学医学院/江苏省非编码RNA重点实验室/江苏省动物重要疫病与人兽共患病防控协同创新中心 |
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| 基金项目： | 国家自然科学基金(81471906);扬州大学大学生学术科技创新项目(X20180700)。 |
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| 摘 要： | 近年来,鲍曼不动杆菌的耐药问题日趋显著。科学家通过改良现有抗生素结构或改变作用靶点的方法,针对耐药菌尝试设计新型抗生素。本文总结了新型抗生素氟环素类、铁载体头孢菌素、新型氨基糖苷类、二氮杂二环辛烷衍生物、多黏菌素B衍生物、基于联苯乙炔的LpxC抑制剂在耐药鲍曼不动杆菌感染治疗中的作用机制、抗菌活性以及安全性。
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| 关 键 词： | 鲍曼不动杆菌 抗药性,细菌 抗菌药 |
Research advances of novel antibiotics in treatment of drug-resistant Acinetobacter baumannii infections |
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| CHEN Jia-hao,LI Guo-cai. Research advances of novel antibiotics in treatment of drug-resistant Acinetobacter baumannii infections[J]. Chinese Journal of New Drugs and Clinical Remedies, 2020, 0(4): 198-203 |
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| Authors: | CHEN Jia-hao LI Guo-cai |
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| Affiliation: | (Yangzhou University Medical College/Jiangsu Key Laboratory of Noncoding RNA/Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases Zoonoses,Yangzhou JIANGSU 225009,China) |
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| Abstract: | In recent years, the problem of drug-resistance of Acinetobacter baumannii has become increasingly significant. Scientists try to design new types of antibiotics against drug-resistant bacteria by improving the structure of existing antibiotics or changing the target. The mechanism of action, antibacterial activity and safety of novel antibiotics such as fluorocyclines, siderophore cephalosporins, novel aminoglycosides, diazabicyclooctanone derivatives, polymyxin B derivatives, and biphenylacetylene-based LpxC inhibitors were summarized in this paper. |
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| Keywords: | Acinetobacter baumannii drug resistance,bacterial anti-bacterial agents |
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