儿童及青少年肾细胞癌预后的荟萃分析研究

目的 本文对儿童及青少年肾细胞癌的预后作进一步研究,利用荟萃分析的方法,进一步探讨儿童及青少年肾细胞癌的生物学行为.方法 利用多种检索策略获得关于儿童及青少年肾细胞癌预后的相关研究.对纳入文献进行Jadad质量分级.提取研究中数据,对总生存率、无病生存率和病理分期进行荟萃分析.所用软件采用RevMan 5.0,共4个研究纳入荟萃分析.结果 TFE3阳性肾细胞癌比TFE3阴性肾细胞癌具有更差的总生存率和无病生存率.TFE3阳性肾细胞癌的病理分期要高(Ⅲ/Ⅳ期)于TFE3阴性肾细胞癌.合并效应量分别为4.59(95％ CI:1.46～14.42)、5.79(95％CI:1.85～18.16)和5.89(95％ CI:2.23～15.52).同时该结果也被生存曲线所验证.结论 TFE3阳性肾细胞癌的预后要差于TFE3阴性肾细胞癌.

The prognosis of juvenile renal cell carcinomas: a meta-analysis of the literature

Objective To define the biological features of juvenile renal cell carcinomas (RCCs)in children and adolescents by systematic review and meta-analysis.Methods Eligible studies were identified through multiple search strategies.Studies were assessed for quality using the Jadad quality scale.Data were collected and analyzed for overall survival (OS),disease-free survival (DFS) and stage in patients with TFE3 + juvenile RCCs and TFE3- RCCs.RevMan 5.0 was used for meta-analyses.Resuits A total of 4 studies were included for meta-analysis.Our meta-analysis outcomes showed that TFE3 + pediatric RCCs were significantly associated with a poorer outcomes (OS and DFS) and a higher stage (Ⅲ/Ⅳ ) than TFE3- RCCs [ pooled ORs for each group: 4.59 (95 ％ CI 1.46 - 14.42) for OS; 5.79 (95％ CI 1.85 - 18.16) for DFS and 5.89 (95％ CI 2.23 - 15.52) for stage].This result was also confirmed by OS and DFS curves (P =0.005 and P =0.001 ).Conclusions Xp1 1.2 transloca tion carcinomas appear to have a poorer prognosis than non-Xp11.2 translocation carcinomas in children and adolescents.