Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory |
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| Authors: | Murray Andrew J Sauer Jonas-Frederic Riedel Gernot McClure Christina Ansel Laura Cheyne Lesley Bartos Marlene Wisden William Wulff Peer |
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| Affiliation: | Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK. |
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| Abstract: | Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory. |
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