Tie-2受体在人脑胶质瘤中的表达及意义

目的测定Tie-2受体在人脑胶质瘤组织中的表达水平,评价其与肿瘤血管生成及临床病理特征的关系。方法采用免疫组化方法,检测42例人脑胶质瘤组织中Tie-2、CD34的蛋白表达情况,并测定肿瘤组织的微血管密度(MVD)。结果Tie-2受体阳性表达主要位于血管内皮细胞内,在肿瘤细胞内仅有少量表达。Tie-2受体表达水平与胶质瘤的临床病理分级、肿瘤内MVD显著相关(P<0.01),而与患者性别、年龄、肿瘤大小无关。结论Tie-2受体可能在胶质瘤血管生成和肿瘤恶性发展中起重要调控作用,有望成为判断胶质瘤恶性程度和预后的重要指标。

Expression of Tie-2 in Human Brain Glioma and Its Significance

Objective To study the relationships among Tie-2, glioma angiogenesis and clinical pathological features. Methods The expressions of Tie-2 and CD34 protein in 42 samples of human gliomas were detected by immunohistochemical technique. The microvascular density was determined in the tumors. Results The expression of Tie-2 was mainly located in the vascular endothelial cells, and rare in glioma cells. Tie-2 was significantly correlated with histopathological grade and MVD of the gliomas (P<0.01), but it was not related with the sex and age of the patients, and the size of the tumors. Conclusions Our observations suggest that tie-2 may play an important role in modulating angiogenesis and malignant development of glioma, and it perhaps may be used for evaluating the tumor malignance degree and prognosis in the patients with gliomas.