Ultrastructural and biosynthetic reactions in cell populations of renal glomeruli of the kidney under conditions of glomerular pathology |
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Authors: | L. M. Nepomnyashchikh G. I. Nepomnyashchikh S. V. Aidagulova T. A. Telegina N. O. Podol'skaya |
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Affiliation: | (1) Laboratory of General Pathological Anatomy, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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Abstract: | Proliferative and degenerative variants of structural and functional changes in the cell populations of renal glomeruli are revealed. These variants differ in the intensity of biosynthetic reactions in endotheliocytes, mesangiocytes, and parietal epitheliocytes. The degenerative variant is characterized by inhibition of RNA and DNA synthesis and ultrastructural alterations in endotheliocytes, which attests to the leading role of damage to glomerular endothelial associations in destruction of renal glomeruli. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 11, pp. 591–596, November, 1999 |
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Keywords: | glomerular pathology nephrobiopsy endothelium radioautography electron microscopy |
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