| 新麻醉药静松灵生物转化的研究 |
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| 引用本文： | 郭联庆,黄如衡.新麻醉药静松灵生物转化的研究[J].药学学报,1990,25(2):95-100. |
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| 作者姓名： | 郭联庆 黄如衡 |
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| 作者单位： | 军事医学科学院毒物药物研究昕，军事医学科学院毒物药物研究昕 北京 100850，北京 100850 |
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| 摘 要： | 静松灵2-(2,4-二甲基苯胺基)-4,5-二氢噻唑,XT]是国内合成的麻醉物,经ip给药后,从大鼠尿中分离、纯化、鉴定了四个代谢产物。MB1即XT原形;MB3及MA2互为异构体,分别为2位、4位甲基氧化为羧基的产物;MA1则4位甲基氧化为羧基,二氢噻唑环中41位亚甲基氧化为羰基。初步实验表明:代谢产物MB3,MA2,MA1的药效与毒性均远低于原形药,大鼠与小鼠对XT的转化机制相近,但也存在种属的差异。
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| 关 键 词： | 静松灵 麻醉药 生物转化 |
| 收稿时间： | 1988-10-31 |
STUDIES ON BIOTRANSFORMATION OF JING SONG LING, A NEW ANESTHETIC |
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| LQ Guo and RH Huang.STUDIES ON BIOTRANSFORMATION OF JING SONG LING, A NEW ANESTHETIC[J].Acta Pharmaceutica Sinica,1990,25(2):95-100. |
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| Authors: | LQ Guo and RH Huang |
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| Institution: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing. |
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| Abstract: | Jing song ling (2,4-xyJidinothiazoline, XT) is a new anestheticagent for veterinary uses in China. From urine of rats given the drug three metabolites (MA_1, MA_2 and MB_3) were isolated with structures shown in page 98 in addition to the parent compound (MB_1). Preliminary observations showed that the toxicity and pharmacological activity of MB_3, MA_2 and MA_1 decreased significantly compared with the parent drug XT. Species difference of biotransformation of XT between rat and mouse was also observed. |
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| Keywords: | 2 4-Xylidinothiazoline Anesthetic Biotransformation |
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