|
|||||
|
|
| 6-(4-取代苯基)-4,5-二氢-3(2H)-哒嗪酮类化合物的合成及其抑制血小板聚集的作用 | |
| 引用本文： | 蒋勤,孙常晟. 6-(4-取代苯基)-4,5-二氢-3(2H)-哒嗪酮类化合物的合成及其抑制血小板聚集的作用[J]. 药学学报, 1990, 25(8): 598-603 |
| 作者姓名： | 蒋勤 孙常晟 |
| 作者单位： | *江苏常州102医院;第二军医大学药学院,上海200433 |
| 摘 要： | 为了寻找较理想的抗血栓药物,本文设计合成了6-(4-取代苯基)-4,5-二氢-3(2H)-哒嗪酮类化合物16个。对ADP诱导的大鼠体外血小板聚集,均有不同程度的抑制作用。其中,化合物Ⅱ2,Ⅱ3和Ⅱ4的作用大于CCI-17810,又以Ⅱ4的作用为最强。 |
| 关 键 词： | 血小板聚集抑制剂 哒嗪酮 |
| 收稿时间： | 1989-07-06 |
SYNTHESIS AND PLATELET AGGREGATION INHIBITORY ACTIVITY OF 6-(4-SUBSTITUTED PHENYL)-4, 5-DIHYDRO -3(2H)-PYRIDAZINONES |
|
| Q Jiang and CS Sun. SYNTHESIS AND PLATELET AGGREGATION INHIBITORY ACTIVITY OF 6-(4-SUBSTITUTED PHENYL)-4, 5-DIHYDRO -3(2H)-PYRIDAZINONES[J]. Acta pharmaceutica Sinica, 1990, 25(8): 598-603 | |
| Authors: | Q Jiang and CS Sun |
| Affiliation: | Faculty of Pharmacy, Second Military Medical College, Shanghai. |
| Abstract: | To search for more ideal antithrombotic drugs sixteen 6-(4-substituted phenyl)-4,5-dihydro-3(2H)-pyridazinones were designed and synthesized. Some improvement of the synthetic method involved in constructing the piperazinyl group by cyclization of bisbromoethyl amine with 4-pyridazinonyl anilines. Preliminary pharmacological tests showed that all of the target compounds inhibited ADP induced platelet aggregation. Compounds II2, II3 and II4 were more potent than CCI-17810. The 5-methyl derivative of CCI-17810 (II4) was the most potent compound. |
| Keywords: | Dihydropyridazinones Platelet aggregation inhibitors |
| 本文献已被 维普 等数据库收录！ | |
| 点击此处可从《药学学报》浏览原始摘要信息 | |
| 点击此处可从《药学学报》下载全文 | |