涂阳肺结核病例1126例化疗效果分析

目的分析临颍县近5年来涂阳肺结核病人的化疗效果，为提高治疗质量提供依据。方法采用含异烟肼、利福平、吡嗪酰胺、乙胺丁醇（HRZE）强化期和HRZ继续期2阶段全程间歇短程化疗方案和全程督导的管理方法。结果初治涂阳病人2、3个月末的痰菌阴转率分别为95．9％和97．1％，治愈率为91．6％；复治涂阳病人的2、3个月末的痰菌阴转率分别为91．3％和94．2％，治愈率为86．0％。结论2个阶段全程间歇的短程化疗方案具有疗效高、不良反应少、经济的优点，全程督导管理是有效的管理方法，值得推广使用。

Chemotherapy Effect on 1126 Cases of Smear-positive TB

[Objective]To analyze the chemotherapy effect on smear-positive TB patients in Linying County in recent 5 years, and provide evidence for improving treatment quality. [ Methods ] Short-course intermittent chemotherapy programs including Isoniazid, rifampicin, pyrazinamide, ethambutol （ HRZE ）reinforcement period and HRZ stage 2 of continued period and full supervision of the management methods were adopted. [ Results] Negative rate of smear-positive patients with initial treatment in 2 and 3 months was 95.9% and 97.1%, respectively, the cure rate was 91.6% ; Negative rate of smear-positive patients with retreatment in 2 and 3 months was 91.3% and 94.2%, respectively. [ Conclusion] The short-course intermittent chemotherapy with 2 stages has the advan- tage of high efficacy, few adverse reaction and economical. Full supervisory management is effective, and worthy of widely use.