肿瘤血管生成机制及抗血管生成药物的研究进展

目的：介绍肿瘤血管生成的机制及其抑制剂的研究进展.方法：查阅国内外相关文献进行总结和归纳.结果：肿瘤血管生成的机制目前发现的有5类：芽生式、套叠式、充塞式、内皮祖细胞的参与、马赛克式及血管生成拟态.目前有一批FDA批准上市的血管生成抑制剂（如贝伐单抗、sunitinib malate和sorafenib等）已用于肿瘤的治疗,还有更多的药物正在研究之中.结论：研究肿瘤血管生成的机制对进一步研究肿瘤血管生成抑制剂有着重要的指导作用.

Advances in research on mechanisms of tumor angiogenesis and antiangiogenic drugs

Objective: To review advances in research on mechanisms of tumor angiogenesis and antiangiogenic drugs.Methods: The domestic and foreign relevant literature was summarized.Results: The mechanisms of tumor angiogenesis included sprouting angiogenesis,intussusceptive angiogenesis,coopted vasculature,recruitment of endothelial progenitor cell,mosaic blood vessel and vasculogenic mimicry.Several antiangiogenic drugs (e.g.bevacizumab,sunitinib malate,sorafenib,etc.) were currently approved by FDA and used clinically to treat cancer and many others were under development.Conclusion: The studies on mechanisms of tumor angiogenesis have important effect on the further research into antiangiogenic drugs.