注射用丹参多酚酸对急性脑梗死患者NIHSS评分、ADL评分和血清NSE、GST的影响

目的 观察注射用丹参多酚酸对急性脑梗死患者美国国立卫生研究院卒中量表（NIHSS）、日常生活活动能力（ADL）评分和血清神经元特异性烯醇化酶（NSE）、谷胱甘肽-S-转移酶（GST）的影响。方法 选取2016年1月1日—2017年7月1日南阳医专第一附属医院神经内科住院的急性脑梗死患者100例为研究对象，按照随机数字表法将患者随机分为对照组和观察组，每组50例。对照组患者在入院后常规治疗，观察组患者在对照组治疗的基础上静脉滴注射用丹参多酚酸，100 mg加入0.9%氯化钠液250 mL静脉滴注，1次/d，连续14 d。分别两组患者NIHSS、ADL评分及GST、NSE水平进行测定。结果 两组患者在治疗后14 d NIHSS评分ADL评分均较治疗前明显改善，差别具有统计学意义（P<0.05）；治疗后14 d，与对照组相比，观察组患者NIHSS评分明显下降，ADL评分明显升高，差别具有统计学意义（P<0.05）。两组患者在治疗后14 d，GST、NSE水平均较治疗前明显改善，差别具有统计学意义（P<0.05）；治疗后14 d，与对照组患者相比，观察组GST及NSE水平改善情况更明显，差别具有统计学意义（P<0.05）。结论 注射用丹参多酚酸能明显提高急性脑梗死患者血清GST水平，降低NSE水平，改善患者ADL、NIHSS评分。

Effects of Salvianolate for Injection on NIHSS score, ADL score, and serum NSE and GST in patients with acute cerebral infarction

Objective To observe the effect of Salvianolate for injection on NIHSS, ADL scores, and serum NSE and GST in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction admitted to the department of neurology, the First affiliated Hospital of Nanyang Medical College from January 1, 2016 to July 1, 2017 were selected. Patients were randomly divided into control group and observation group according to the random number table method, with 50 cases in each group. Patients in the control group received routine treatment after admission, and patients in the observation group received intravenous infusion of Salvianolate for injection on the basis of control group, 100 mg was added with 0.9% sodium chloride solution 250 mL, once daily for 14 consecutive days. And the NIHSS, ADL scores, and the levels of GST and NSE were measured in two groups. Results After treatment of 14 d, NIHSS score and ADL score in two groups were significantly improved (P < 0.05). After treatment of 14 d, compared with control group, the NIHSS score in the observation group were significantly decreased, and the ADL score were significantly increased, with statistically significant difference (P < 0.05). After treatment of 14 d, the levels of GST and NSE in two groups were significantly improved, with statistically significant differences (P < 0.05). After treatment of 14 d, compared with the control group, GST and NSE levels in the observation group improved more significantly, with statistically significant differences (P < 0.05). Conclusion Salvianolate for injection can significantly improve the levels of serum GST, reduce the level of NSE, and improve the ADL and NIHSS scores of patients with acute cerebral infarction.