Epidermal growth factor receptor structural alterations in gastric cancer |
| |
Authors: | Cátia Moutinho Ana R Mateus Fernanda Milanezi Fátima Carneiro Raquel Seruca Gianpaolo Suriano |
| |
Affiliation: | 1.Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP),Porto,Portugal;2.Technische Universit?t München, Klinikum rechts der Isar,Institut für Allgemeine Pathologie und Pathologische Anatomie,München,Germany;3.Faculdade de Medicina da Universidade do Porto,Porto,Portugal |
| |
Abstract: |
Background EGFR overexpression has been described in many human tumours including gastric cancer. In NSCLC patients somatic EGFR mutations, within the kinase domain of the protein, as well as gene amplification were associated with a good clinical response to EGFR inhibitors. In gastric tumours data concerning structural alterations of EGFR remains controversial. Given its possible therapeutic relevance, we aimed to determine the frequency and type of structural alterations of the EGFR gene in a series of primary gastric carcinomas. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|