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Epidermal growth factor receptor structural alterations in gastric cancer
Authors:Cátia Moutinho  Ana R Mateus  Fernanda Milanezi  Fátima Carneiro  Raquel Seruca  Gianpaolo Suriano
Affiliation:1.Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP),Porto,Portugal;2.Technische Universit?t München, Klinikum rechts der Isar,Institut für Allgemeine Pathologie und Pathologische Anatomie,München,Germany;3.Faculdade de Medicina da Universidade do Porto,Porto,Portugal
Abstract:

Background  

EGFR overexpression has been described in many human tumours including gastric cancer. In NSCLC patients somatic EGFR mutations, within the kinase domain of the protein, as well as gene amplification were associated with a good clinical response to EGFR inhibitors. In gastric tumours data concerning structural alterations of EGFR remains controversial. Given its possible therapeutic relevance, we aimed to determine the frequency and type of structural alterations of the EGFR gene in a series of primary gastric carcinomas.
Keywords:
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