Lipoprotein(a) Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Mononuclear Cells |
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| Authors: | Mihai G. Netea Natasja de Bont Pierre N. M. Demacker Bart Jan Kullberg Liesbeth E. H. Jacobs Trees J. G. Verver-Jansen Anton F. H. Stalenhoef Jos W. M. Van der Meer |
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| Affiliation: | Division of General Internal Medicine, Department of Medicine, University Hospital Nijmegen, 6500 HB Nijmegen, The Netherlands |
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| Abstract: | Lipoproteins can bind lipopolysaccharide (LPS) and decrease LPS-stimulated cytokine production. Lipoprotein(a) [Lp(a)] was as potent as low-density lipoproteins (LDL) in inhibiting LPS-stimulated tumor necrosis factor synthesis by human mononuclear cells. The kinetics of LPS inhibition by Lp(a) was similar to that of LDL. This suggests that circulating Lp(a) may be an important factor determining the amplitude of the response to LPS in humans. |
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