GSTM1、GSTT1基因多态性与亚洲男性特发性不育症易感性相关性Meta分析

目的:探讨人群谷胱甘肽S-转移酶基因多态性与亚洲男性特发性不育易感性的关系。方法:检索pubmed,sciencedirect,springer,China biological medicine(CBM)、中国知网、万方、维普数据库从建库到2016年5月的文献,对所纳入的病例-对照研究,运用Rev Man4.2软件进行Meta分析。结果:共纳入14篇病例对照研究,关于GSTM1基因缺失型与不育症关系的研究总共纳入病例组3404人、对照组2308人,关于GSTT1基因缺失型与不育症关系的研究总共纳入病例组3143人、对照组2017人。Meta分析显示:(1)亚洲人群中GSTM1缺失基因型与原发性男性不育症易感性相关性有统计学意义(OR=1.30,95%CI=1.01~1.66,P0.05);亚组分析,东亚人群(OR=1.08,95%CI=0.94~1.23,P=0.260.05)、南亚人群(OR=1.06,95%CI=0.52~2.18,P=0.870.05)的GSTM1缺失基因型均与原发性男性不育症易感性相关性无统计学意义;而西亚人群(OR=2.01,95%CI=1.64~2.67,P=0.00010.05)的GSTM1缺失基因型与原发性男性不育症易感性有显著统计学意义;2、亚洲人群中GSTT1缺失基因型与原发性男性不育症易感性相关性无统计学意义(OR=1.20,95%CI=0.93~1.54,P0.05)。亚分组分析:东亚人群(OR=1.13,95%CI=0.89~1.44,P=0.330.05)和西亚人群(OR=1.65,95%CI=0.98~2.77,P=0.060.05)中GSTT1缺失基因型均与原发性男性不育症易感性相关性无统计学意义。结论:亚洲人群中GSTM1缺失基因型可能增加原发性男性不育症易感性;亚洲人群中GSTT1缺失基因型与原发男性不育症未见相关性。

Correlation of the glutathione S-transferase gene polymorphism(GSTM1 and GSTT1) and the Asian male idiopathic infertility: a meta-analysis

Objectives:To explore the relationship between the glutathione S-transferase gene polymorphism (GSTM1 and GSTT1) and the Asian male idiopathic infertility.Methods:Related literature published in PubMed,ScienceDirect,Springer,China Biological Medicine (CBM),China National Knowledge Infrastructure (CNKI),Wanfang,Weipu and other databases up to December 2015 were searched,and case-control studies were included for meta-analysis by using RevMan 4.2 software.Results:14 case-control studies were included in the study,including a total of 3404 idiopathic infertility males and 2308 controls on GSTM1 polymorphism and a total of 3143 idiopathic infertility males and 2017 controls on GSTT1 polymorphism.According to meta-analysis,GSTM1 null genotype in Asian was significantly associated with an increased risk of male idiopathic infertility (OR =1.30,95％ CI=1.01 ～ 1.66,P =0.04 ＜0.05).In terms of the sub-groups,the east Asian people (OR =1.08,95％ CI=0.94～1.23,P=0.26＞0.05) and the south Asian people (OR=1.06,95％ CI=0.52～ 2.18,P =0.87 ＞0.05) lack of GSTM1 genotypes were not significantly susceptible to primary male infertility,but the west Asian was significantly susceptible (OR =2.01,95 ％ CI =1.64 ～ 2.67,P =0.0001 ＜ 0.05).2.GSTT1 null genotype in Asian was insignificantly associated with an increased risk of male idiopathic infertility (OR =1.20,95％ CI =0.93 ～ 1.54,P =0.16 ＞0.05).In terms of the sub-groups,the east and west Asian people lack of GSTM1 genotypes were not significantly susceptible to primary male infertility (OR =1.13,95％ CI =0.89 ～1.44,P=0.33 ＞0.05;OR=1.65,95％ CI=0.98～2.77,P=0.06＞0.05).Conclusion:GSTM1 null genotype in Asian is significantly associated with an increased risk of male idiopathic infertility while the GSTT1 is not on the whole.