少弱精症患者血液微量元素与精液质量的临床研究

目的:研究少弱精症患者血液微量元素与精液质量的相关性,以期指导临床治疗。方法:选取2014年1月至2015年1月间来院诊治的少精弱精症患者78例作为观察组,同时选取同期入院体检的健康男性42例作为对照组。两组男性均行常规精液分析与血液微量元素的含量检测。结果:观察组血清钙与铜的含量与对照组差异并不显著;而观察组血清含锌量为(7.23±2.70)μmol/L、含铅量为(29.33±15.97)μg/L,对照组则分别为(13.37±2.34)μmol/L、含铅量为(7.09±5.74)μg/L,两组差异显著(P0.05)。观察组血清锌含量与精子活率负相关(r=-0.162,P0.05),含铅量与精子密度、正常形态精子率、精子活率均负相关(r分别为-0.112、-0.067、-0.142,P0.05),含铜量与精子密度正相关而与前向运动精子率负相关(r分别为0.058、-0.137,P0.05)。结论:少弱精症患者血液锌、铅、铜的含量与精液质量密切相关,严密监测可指导临床治疗。

Correlation between the trace elements in blood and semen quality of patients with asthenozoospermia

Objectives:To study the correlation between the serum trace elements and semen quality of patients with asthenozoospermia in order to guide the clinical treatment.Methods:78 patients with asthenozoospermia in our hospital from January 2014 to January 2015 were selected as the observation group,while 42 healthy men in the hospital for physical examination in the same time were selected as control group.All subjects underwent routine semen analysis and content detection of trace elements in the blood.Results:The differences in serum calcium and copper between the two groups were not significant.The serum zinc content and lead content in the observation group were (7.23 ±2.70) μmol / L and (29.33 ± 15.97) μg / L respectively,while those in the control group were respectively (13.37 ± 2.34) μmol / L and (7.09 ± 5.74) μg / L,with significant difference (P ＜ 0.05).In the observation group,there was a negative correlation between serum zinc content and sperm motility (r =-0.162,P ＜ 0.05),a negative correlation between the lead content and sperm density,normal sperm morphology rate,sperm motility rate (r =-0.112,-0.067,-0.142,P ＜ 0.05),and negative correlation between the copper content and sperm density positively correlated with the forward movement of sperm rate negatively correlated (r =0.058,-0.137,P ＜ 0.05).Conclusion:The serum zinc,lead and copper content is closely related to the quality of semen in patients with asthenozoospermia,so close monitoring is necessary to guide the clinical treatment.