比较盐酸利托君和阿托班西对35岁以上先兆早产妇女保胎效果、围生儿结局及不良反应发生率的影响

目的分析盐酸利托君与阿托西班对≥35岁先兆早产妇女保胎效果、围生儿结局及不良反应发生率的影响。方法选取绵阳市人民医院2014年1月至2015年1月收治的≥35岁的先兆早产妇女共130例,以随机抽签法分为两组各65例,A组予盐酸利托君治疗,B组予阿托西班治疗。比较两组保胎成功率、分娩孕周、低体重儿发生率、新生儿窒息发生率、围生儿死亡率、不良反应发生率、呼吸频率及心率等情况。结果两组保胎成功率、分娩孕周、低体重儿发生率、新生儿窒息发生率及围生儿死亡率比较差异均无统计学意义(P0.05);B组不良反应发生率、用药后呼吸频率和心率、分娩后肌酸激酶同工酶和乳酸脱氢酶水平均显著低于A组,差异有统计学意义(P0.05)。结论盐酸利托君与阿托西班治疗≥35岁妇女先兆早产均能取得较好的保胎效果和围生儿结局,但阿托西班安全性更佳。

Effect comparison of ritodrine hydrochloride and atosiban on fetus protection,perinatal fetal outcomes and incidence of adverse reactions of threatened premature women aged over 35

Objective To investigate the effect of ritodrine hydrochloride and atosiban on fetus protection, perinatal fetal outcomes and incidence of adverse reactions of threatened premature women aged ≥35.Methods A total of 130 cases of threatened premature women aged ≥35 years admitted to Mianyang People's Hospital from January 2014 to January 2015 were randomly divided into two groups, with 65 cases each.Group A were treated with ritodrine hydrochloride and group B with atosiban.Fetus protection effects,gestational week,incidence of low birth weight infants,neonatal asphyxia, perinatal mortality, incidence of adverse reactions, respiratory rate and heart rate of both groups were compared.Results There was no significant difference in the fetus protection effects,gestational week,incidence of low birth weight infants,neonatal asphyxia and perinatal mortality between the two groups(P<0.05).While incidence of adverse reactions, respiratory rate and heart rate after treatment, levels of creatine kinase isoenzyme(CK-MB) and lactate dehydrogenase (LDH) after pregnancy of group B were significantly lower than that of group A(P<0.05).Conclusion Both ritodrine hydrochloride and atosiban used in the treatment of threatened premature women≥ 35 years old can achieve fetus protection effect and perinatal fetal outcomes, but the safety of atosiban is better.