| 高效液相色谱法测定肌醇烟酸脂及其制剂的有关物质 |
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| 引用本文： | 王宪忠,王丹彧,李东伟,张椿影,陈笑强.高效液相色谱法测定肌醇烟酸脂及其制剂的有关物质[J].中国科学美容,2011(18):34-35,37. |
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| 作者姓名： | 王宪忠 王丹彧 李东伟 张椿影 陈笑强 |
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| 作者单位： | [1]吉林省四平市食品药品检验所,吉林四平136000 [2]黑龙江省齐齐哈尔市第一医院,黑龙江齐齐哈尔161005 |
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| 摘 要： | 目的建立高效液相色谱法测定肌醇烟酸脂的有关物质。方法色谱柱为Diamonsil-C18,流动相为水-甲醇-四氢呋喃（45：45：10）,检测波长262nm,流速1.0mL/min,进样量10μL。采用自身对照法。结果最大杂质峰不超过对照溶液主峰,其杂质峰面积之和不超过对照溶液主峰。结论本方法能灵敏、准确、可靠的进行杂质检测,对肌醇烟酸脂有关物质的控制有一定意义。
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| 关 键 词： | 高效液相色谱法 有关物质 肌醇烟酸脂 |
Determination of niacin inositol lipid related substances and preparations |
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| WANG Xianzhong,WANG Danyu,LI Dongwei,ZHANG Chunying,CHEN Xiaoqiang.Determination of niacin inositol lipid related substances and preparations[J].China Scientific Cosmetology,2011(18):34-35,37. |
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| Authors: | WANG Xianzhong WANG Danyu LI Dongwei ZHANG Chunying CHEN Xiaoqiang |
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| Institution: | 1.Siping Institute for Food and Drug Control in Jilin Province,Siping 136000,China;2.First Hospital of Qiqihar City in Heilongjiang Province,Qiqihar 161005,China |
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| Abstract: | Objective To establish a high-performance liquid chromatography（HPLC）inositol niacin fat related substances.Methods We used chromatographic column for Diamonsil-C18,mobile phase for water-methanol-THF（45：45：10）,detected wavelength 262 nm,velocity 1.0 mL/min,incoming sample amount 10μL.We used self-control contrast method.Results The biggest impurity peak did not exceed reference solution,the peak of impurity peak area of sum does not exceed reference solution peaks.Conclusion The method can sensitive,accurate and reliable for impurities testing,the inositol niacin fat related substances control has certain significance. |
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| Keywords: | High performance liquid chromatography Related substances Inositol niacin fat |
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