IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients |
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| Authors: | Nicolas Couturier Pierre-Antoine Gourraud Isabelle Cournu-Rebeix Claire Gout Florence Bucciarelli Gilles Edan Marie-Claude Babron Fran?oise Clerget-Darpoux Michel Clanet Bertrand Fontaine David Brassat |
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| Affiliation: | 1.INSERM U563, and Pôle des neurosciences, Université Toulouse 3, Toulouse, France;2.INSERM U558, Département d''épidémiologie et de santé publique, Université Toulouse 3, Toulouse, France;3.INSERM U546, Faculté de Médecine Pitié-Salpêtrière, Paris, France;4.Département de Neurologie, CHU Pontchaillou, Rennes, France;5.INSERM U535, Université de Paris Sud, Villejuif, France |
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| Abstract: | ![]()
A recent investigation reported, for the first time, an association between variants in the IFIH1-GCA-KCNH7 locus and multiple sclerosis (MS). We sought to replicate this genetic association in MS with a new independent MS cohort composed of French Caucasian MS trio families. The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were genotyped in 591 French Caucasian MS trio families, and analyzed using the transmission/disequilibrium test. No association with MS was found (rs1990760, P=0.45 and rs2068330, P=0.27). Similarly, no significant association was detected after stratification for HLA-DRB1*1501 carriers. Reasons that may explain this discrepancy between the original report and our study are discussed. |
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| Keywords: | IFIH1 multiple sclerosis interferon-induced protein autoimmune disease genetic association study |
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