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Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice |
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| Authors: | Song Yiyun Shan Shifang Zhang Ying Liu Wei Ding Weiqiao Ren Wenxia Xia Hongfeng Li Xiaojun Zhang Qin Zhao Lei Li Xihua Yan Jun Ying Hao |
| Affiliation: | 1 Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China 2 Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China 3 Department of Neuromuscular Disease, Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China 4 Department of Neuromuscular Disease, Children’s Hospital of Fudan University, Shanghai 201102, China 5 Model Animal Research Center and MOE Key Laboratory of Model Animals for Disease Study, Nanjing University, Nanjing 210061, China 6 Zhejiang Provincial Key Lab for Technology and Application of Model Organisms, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China |
| Abstract: | |
| Keywords: | LCOR, ligand-dependent corepressor ob/ob, leptin-deficient TR, thyroid hormone receptor TH, thyroid hormone SRC, steroid receptor coactivators PGC-1, peroxisome proliferator-activated receptor gamma coactivator-1 NCOR, nuclear receptor corepressor SMRT, silencing mediator for retinoic acid receptor and thyroid hormone receptor RIP140, nuclear receptor co-repressor nrip1 HDAC, histone deacetylases CtBP, C-terminal binding protein ME, malic enzyme FAS, fatty acid synthase ACC, acetyl-CoA carboxylase SP14, thyroid hormone responsive SPOT14 T3, Triiodothyronine TRE, thyroid hormone response elements LFD, low-fat diet HFD, high-fat diet TG, triglyceride MMI, methimazole ChIP, chromatin immunoprecipitation DIO1, deiodinase I LBD, ligand-binding domain Td, T3 deficient |
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