| 大鼠短间隔连续部分肝切除后ADAMsmRNA表达分析 |
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| 引用本文： | 李玉昌,林俊堂,梁卫红,徐存拴,马军. 大鼠短间隔连续部分肝切除后ADAMsmRNA表达分析[J]. 胃肠病学和肝病学杂志, 2001, 10(3): 235-237 |
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| 作者姓名： | 李玉昌 林俊堂 梁卫红 徐存拴 马军 |
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| 作者单位： | 1. 河南师范大学生命科学学院
2. 郑州大学消化疾病研究所 |
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| 基金项目： | 国家自然科学基金资助项目(N039970362)和河南省生物工程重点实验室资助项目(PKL99001)作者介绍李玉昌,男,30岁,博士研究生.研究方向:细胞分化和去分化分子生物学.E-mail:lvchang@mailhenannu edu.cn |
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| 摘 要： | 目的说明ADAMs(a disintegrin andmetalloproteinase)在肝再生的不同阶段表达不同.方法用RT-PCR方法和ADAMs通用引物对本实验建立的大鼠短间隔连续部分肝切除(shortinterval successive partial hepatectomy,SISPH)模型0、4、8、12hr,0、36、72、108、144hr及0、4、40、76、112hr肝再生过程中的mRNA进行分析.结果正常大鼠和SISPH后大鼠肝脏均存在ADAMs的表达、但表达强度不同.结论本组资料显示ADAMs可能对肝再生过程具有调控作用
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| 关 键 词： | ADAMs |
| 修稿时间： | 2001-01-15 |
Analysis of ADAMs mRNA Expression Following Short Interval Successive PartialHepatectomy in Rat Liver |
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| Li Yuchang,Ma Jun,Lin Juntang,et al College of Life Sciences,Henan Normal University,Xinxiang. Analysis of ADAMs mRNA Expression Following Short Interval Successive PartialHepatectomy in Rat Liver[J]. Chinese Journal of Gastroenterology and Hepatology, 2001, 10(3): 235-237 |
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| Authors: | Li Yuchang Ma Jun Lin Juntang et al College of Life Sciences Henan Normal University Xinxiang |
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| Affiliation: | Li Yuchang,Ma Jun,Lin Juntang,et al College of Life Sciences,Henan Normal University,Xinxiang 453002 |
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| Abstract: | Aim To suggest that ADAMs perform different functions in different stage in liver regeneration.Methods RT-PCR was used to analyze the expression of mRNA in three models, 0?4?8?12 hr,0?36?72?108?144 hr and 0?4?40?76?112 hr short interval successive partial hepatectomy (SISPH) with ADAMs general primers.Results ADAMs expressed in control and treated rat liver, but expression degree were different.Conclusions ADAMs may perform regulative functions during liver regeneration. |
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| Keywords: | ADAMs SISPH General primers RT-PCR Liver regeneration |
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