| pH/温度双敏感水凝胶合成与释药性质研究 |
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| 引用本文： | 薛 丰,U. Gianfranco Spizzirri,平其能,肖衍宇,操 锋,费 佳.pH/温度双敏感水凝胶合成与释药性质研究[J].药学与临床研究,2010,18(3):218-221. |
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| 作者姓名： | 薛 丰 U. Gianfranco Spizzirri 平其能 肖衍宇 操 锋 费 佳 |
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| 作者单位： | 1. 中国药科大学药剂学教研室,南京,210009
2. Dipartimento di Scienze Farmaceutiche, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy |
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| 基金项目： | 国家重大新药创制科技重大专项资助项目 |
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| 摘 要： | 目的:合成一种同时具有pH和温度敏感性的水凝胶,并研究其载药、释药机理.方法:利用反相悬浮聚合法合成基于温度敏感材料N-异丙基丙烯酰胺、pH敏感材料甲基丙烯酸与N,N'-亚甲基双丙烯酰胺的共聚物,以双氯芬酸钠为模型药,测定在不同溶剂中水凝胶的载药能力;并测定了在不同pH环境(pH1,pH4和pH7)、不同温度下(25℃和37℃),双敏感水凝胶的释放性质.结果:实验表明药物在低温、低pH条件下保持收缩状态,药物基本不能从中释放;在高温、高pH状态下药物迅速释放,凝胶微球有较强的温度/pH敏感性质.结论:所得双敏感水凝胶具有显著的pH/温度敏感性质,可应用于药物口服给药.
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| 关 键 词： | 水凝胶 温度敏感 pH敏感 双氯芬酸钠 |
| 收稿时间： | 2010/3/9 0:00:00 |
| 修稿时间： | 2010/3/22 0:00:00 |
Drug Load and Release Behavior of a pH/ Thermo-sensitive Hydrogel |
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| XUE Feng,U. Gianfranco Spizzirri,PING Qi-neng,XIAO Yan-yu,CAO Feng and FEI Jia.Drug Load and Release Behavior of a pH/ Thermo-sensitive Hydrogel[J].Pharmacertical and Clinical Research,2010,18(3):218-221. |
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| Authors: | XUE Feng U Gianfranco Spizzirri PING Qi-neng XIAO Yan-yu CAO Feng and FEI Jia |
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| Institution: | Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;Dipartimento di Scienze Farmaceutiche, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Objective: To synthesize a hydrogel with pH/thermo dual-sensitive property and study its drug loading and releasing behavior. Method: A reverse phase suspension polymerization reaction based on thermo-sensitive material N-isopropylacrylamide, pH sensitive |
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| Keywords: | Hydrogel Thermo sensitive pH sensitive Diclofenac sodium |
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