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Strain‐encoded (SENC) magnetic resonance imaging to evaluate regional heterogeneity of myocardial strain in healthy volunteers: Comparison with conventional tagging
Authors:Mirja Neizel MD  Dirk Lossnitzer MD  Grigorios Korosoglou MD  Tim Schäufele MD  Antje Lewien  Henning Steen MD  Hugo A. Katus PhD  Nael F. Osman PhD  Evangelos Giannitsis MD
Affiliation:1. Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany;2. Mirja Neizel and Dirk Lossnitzer contributed equally to this work.;3. Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA
Abstract:

Purpose

To evaluate the ability of strain‐encoded (SENC) magnetic resonance imaging (MRI) for regional systolic and diastolic strain analysis of the myocardium in healthy volunteers.

Materials and Methods

Circumferential and longitudinal peak systolic strain values of 75 healthy volunteers (35 women and 40 men, mean age 44 ± 12 years) were measured using SENC at 1.5T. MR tagging was used as the reference standard for measuring regional function. Diastolic function was assessed in the 10 youngest (24 ± 8 years) and 10 oldest (62 ± 5 years) subjects.

Results

Peak strain values assessed with SENC were comparable to those obtained by MR tagging, showing narrow limits of agreement (limits of agreement ?5.6% to 8.1%). Regional heterogeneity was observed between different segments of the left ventricle (LV) by both techniques (P < 0.001). Longitudinal strain obtained by SENC was also heterogenous (P < 0.001). Interestingly, no age‐ or gender‐specific differences in peak systolic strain were observed, whereas the peak rate of relaxation of circumferential strain rate was decreased in the older group.

Conclusion

SENC is a reliable tool for accurate and objective quantification of regional myocardial systolic as well as diastolic function. In agreement with tagged MRI, SENC detected slightly heterogeneous myocardial strain within LV segments. J. Magn. Reson. Imaging 2009;29:99–105. © 2008 Wiley‐Liss, Inc.
Keywords:strain‐encoded imaging  magnetic resonance imaging  myocardial strain  diastolic function  normal ventricle
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