Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one,fluocinolone acetonide |
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| Authors: | D. Zhong Anita H. Lewin |
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| Affiliation: | Center for Organic and Medicinal Chemistry, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC 27709, USA |
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| Abstract: | ![]()
Fluocinolone acetonide was tritiated by selective reduction of the 1,2‐double bond of the O‐protected analog under tritium, followed by re‐establishment of the 1,2‐double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8 Ci/mmol. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | NSC92339 tritium oxidative de‐hydrogenation |
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