Validation and reproducibility of aortic pulse wave velocity as assessed with velocity‐encoded MRI |
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| Authors: | Heynric B. Grotenhuis MD Jos J.M. Westenberg PhD Paul Steendijk PhD Rob J. van der Geest MS Jaap Ottenkamp MD Jeroen J. Bax MD J. Wouter Jukema MD Albert de Roos MD |
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| Affiliation: | 1. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands;2. Department of Paediatric Cardiology, CAHAL: Center for Congenital Anomalies of the Heart, Leiden University Medical Center, Leiden;3. Emma Children's Hospital / AMC, Amsterdam;4. VU Medical Center, Amsterdam;5. The Netherlands;6. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands;7. Department of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands |
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| Abstract: | ![]()
Purpose To validate magnetic resonance imaging (MRI) assessment of aortic pulse wave velocity (PWVMRI) with PWV determined from invasive intra‐aortic pressure measurements (PWVINV) and to test the reproducibility of the measurement by MRI. Materials and Methods PWVMRI was compared with PWVINV in 18 nonconsecutive patients scheduled for catheterization for suspected coronary artery disease. Reproducibility of PWVMRI was tested in 10 healthy volunteers who underwent repeated measurement of PWVMRI at a single occasion. Velocity‐encoded MRI was performed on all participants to assess PWVMRI in the total aorta (Aototal), the proximal aorta (Aoprox), and the distal aorta (Aodist). Results The results are expressed as mean ± SD, Pearson correlation coefficient (PCC), and intraclass correlation (ICC). Good agreement between PWVMRI and PWVINV was found for Aototal (6.5 ± 1.1 m/s vs. 6.1 ± 0.8 m/s; PCC = 0.53), Aoprox (6.5 ± 1.3 m/s vs. 6.2 ± 1.1 m/s; PCC = 0.69), and for Aodist (6.9 ± 1.1 m/s vs. 6.1 ± 1.0 m/s; PCC = 0.71). Reproducibility of PWVMRI was high for Aototal (4.3 ± 0.5 m/s vs. 4.6 ± 0.7 m/s; ICC = 0.90, P < 0.01), Aoprox (4.3 ± 0.9 m/s vs. 4.7 ± 1.0 m/s; ICC = 0.87, P < 0.01), and Aodist (4.3 ± 0.6 m/s vs. 4.4 ± 0.8 m/s; ICC = 0.92, P < 0.01). Conclusion MRI assessment of aortic pulse wave velocity shows good agreement with invasive pressure measurements and can be determined with high reproducibility. J. Magn. Reson. Imaging 2009;30:521–526. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | pulse wave velocity magnetic resonance imaging aorta elasticity coronary artery disease |
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