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Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion‐weighted and magnetization transfer imaging: The LADIS (leukoaraiosis and disability in the elderly) study |
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| Authors: | Stefan Ropele PhD Alexandra Seewann MD Alida A. Gouw MD Wiesje M. van der Flier MD Reinhold Schmidt MD Leonardo Pantoni MD PhD Domenico Inzitari MD Timo Erkinjuntti MD PhD Philip Scheltens MD PhD Lars O. Wahlund MD PhD Gunhild Waldemar MD DMSc Hugues Chabriat MD PhD José Ferro MD PhD Michael Hennerici MD John O'Brien MD Anders Wallin MD PhD Peter Langhorne MD PhD Marieke C. Visser MD PhD Frederik Barkhof MD PhD Franz Fazekas MD |
| Affiliation: | 1. Department of Neurology, Medical University of Graz, Austria;2. Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands;3. Department of Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands;4. Department of Neuroradiology, Medical University of Graz, Austria;5. Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy;6. Memory Research Unit, Department of Clinical Neurosciences, Helsinki University, Helsinki, Finland;7. Neurotec Department, Section of Clinical Geriatrics, Karolinska Institute, Huddinge, Sweden;8. Memory Disorders Research Unit, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark;9. Department of Neurology, H?pital Lariboisière, Paris, France;10. Servi?o de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal;11. Department of Neurology, University of Heidelberg, Klinikum Mannheim, Mannheim, Germany;12. Institute for Ageing and Health, University of Newcastle, Newcastle‐upon‐Tyne, United Kingdom;13. Institute of Clinical Neuroscience, G?teborg University, G?teborg, Sweden;14. Academic Section of Geriatric Medicine, Royal Infirmary, Glasgow, United Kingdom |
| Abstract: | PurposeTo explore the value of diffusion‐weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH).Materials and MethodsDWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65‐ to 85‐year‐old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score.ResultsADC and MTR values showed a significant inter‐site variation, which was stronger for the MTR. After z‐transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity.ConclusionADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings. J. Magn. Reson. Imaging 2009;29:268–274. © 2009 Wiley‐Liss, Inc. |
| Keywords: | brain ageing white matter hyperintensities magnetization transfer diffusion |