Interleukin‐18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease |
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| Authors: | Shih‐Yin Chen Lei Wan Yu‐Chuen Huang Jim Jinn‐Chyuan Sheu Yu‐Ching Lan Chih‐Ho Lai Cheng‐Wen Lin Jeng Sheng Chang Yuhsin Tsai Shih‐Ping Liu Ying‐Ju Lin Fuu‐Jen Tsai |
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| Affiliation: | 1. Department of Medical Research, Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan;2. Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan;3. S.Y. Chen, Ph.D., L. Wan, Ph.D., and Y.‐C. Huang, Ph.D. are joint first authors and equal contributed to this study.;4. Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan;5. Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan;6. Institute of Physics, Academia Sinica, Taipei, Taiwan;7. Department of Health Risk Management, China Medical University, Taichung, Taiwan;8. Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan;9. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan;10. Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan;11. Center for Neuropsychiatry, China Medical University and Hospital, Taichung, Taiwan;12. Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan;13. F.‐J. Tsai and Y.‐J. Lin are joint corresponding authors.;14. Department of Medical Research, Department of Medical Genetics, Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan |
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| Abstract: | Interleukin‐18 (IL‐18)‐656T/G, ‐607A/C, and ‐137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An IL‐18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL‐18 105A/C genetic polymorphism confers KD susceptibility. Study participants were Taiwanese KD patients and a healthy control group. Our data indicated that the frequency of C allele was significantly higher in the patient group (13.9%) than in the control group (2.7%; P<0.0001, odds ratio [OR]=5.93; 95% confidence interval [CI]=2.57–13.73). Therefore, persons with the C allele may have higher risk of deve loping KD. In addition, compared with the haplotype frequencies between case and control groups, the KD patients with TACC haplotype appeared to be a significant “at‐risk” haplotype compared with other haplotypes (OR: 4.62, 95% CI: 1.71–12.43; P=0.001). KD patient with the TAGA haplotype appeared to be a significant “protective” haplotype compared with other haplotypes (OR: 0.51, 95% CI:0.29–0.89; P=0.017). Our results suggest that 105A/C polymorphism and the haplotypes in IL‐18 gene are associated with the risk of KD in Taiwanese population. Clin. Lab. Anal. 23:71–76, 2009. © 2009 Wiley‐Liss, Inc. |
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| Keywords: | Kawasaki disease (KD) interleukin 18 (IL‐18) polymorphism |
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