Radiosynthesis of [3H]‐ABP688 using [3H]‐methyl nosylate: a non‐volatile alternative methylating agent |
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| Authors: | Pixu Li John D. Olszewski |
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| Affiliation: | Wyeth Research, Chemical Development–Radiosynthesis, 401 North Middletown Road, Pearl River, NY 10965, USA |
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| Abstract: | Tritiated ABP688 was synthesized from desmethyl ABP688 with [3H]‐methyl nosylate in high radiochemical yield. The results demonstrate that [3H]‐methyl nosylate is a good alternative methylating agent for radiosynthesis. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | tritiation radiosynthesis methylation mGlu5 receptor antagonist |
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