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| 膀胱肿瘤6号染色体长臂的杂合性缺失研究 | |
| 引用本文： | 成凡,楚雍烈,贺大林,杨林,陈萍,杨娥,刘湘. 膀胱肿瘤6号染色体长臂的杂合性缺失研究[J]. 中国康复理论与实践, 2004, 10(5): 279-280 |
| 作者姓名： | 成凡 楚雍烈 贺大林 杨林 陈萍 杨娥 刘湘 |
| 作者单位： | 1. 710061,陕西西安市,西安交通大学医学院微生物教研室;710068,陕西西安市,陕西医学高等专科学校生化教研室 2. 710061,陕西西安市,西安交通大学医学院微生物教研室 3. 710061,陕西西安市,西安交通大学第一附属医院泌尿外科 |
| 摘 要： | 目的探讨 6号染色体长臂的杂合性缺失 (LOH)与膀胱肿瘤的关系。方法应用 6q2 1区域附近D6S40 4、D6S43 4微卫星标志 ,以PCR SSLP 银染法对 3 1例膀胱肿瘤患者的肿瘤组织进行杂合性缺失的研究。结果膀胱肿瘤组织D6S40 4LOH发生率为 3 5 5 %,D6S43 4LOH发生率为 2 2 6%。结论 6q2 1区域附近可能存在与膀胱肿瘤相关的肿瘤抑制基因。 |
| 关 键 词： | 膀胱肿瘤 杂合性缺失 6号染色体长臂(6q) |
| 文章编号： | 1006-9771(2004)05-0279-02 |
| 修稿时间： | 2004-03-08 |
Loss of heterozygosity of microsatellite DNA on 6q in bladder tumor |
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| CHENG Fan,CHU Yong-lie,HE Da-lin,et al.. Loss of heterozygosity of microsatellite DNA on 6q in bladder tumor[J]. Chinese Journal of Rehabilitation Theory and Practice, 2004, 10(5): 279-280 | |
| Authors: | CHENG Fan CHU Yong-lie HE Da-lin et al. |
| Affiliation: | CHENG Fan,CHU Yong-lie,HE Da-lin,et al.Department of Microbiology,Medical College of Xi'an Jiaotong University,Xi'an 710068,Shaanxi,China |
| Abstract: | ObjectiveTo investigate the loss of heterozygosity (LOH) on 6q in bladder tumor.MethodsD6S404 and D6434 microsatellite markers near 6q21 were tested by PCR-SSLP-stain method on tumor DNA from 31 cases of bladder tumor.ResultsAmong these 31 cases of bladder tumor,LOH was detected in tumor tissues on site for D6S404 (35.5%) and D6S434(22.6%).ConclusionOne or more tumor suppressor gene near 6q21 maybe relevant for the development of bladder tumor. |
| Keywords: | bladder tumor loss of heterozygosity (LOH) long arm of chromosome 6(6q) |
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