血清B族维生素含量与癫痫相关性分析

目的 探讨B族维生素（B1、B6、B12）与癫痫发生的相关性.方法 选取2013年1至10月新诊断的癫痫患儿（均未服用抗癫痫药物）与非癫痫患儿各50例,应用LK3000V维生素检测仪分别检测各组血清B族维生素（B1、B6、B12）浓度.结果 癫痫患儿血清中维生素B1和B12的浓度分别为（132.81 ±7.31） nmol/L和（221.41±26.09） pg/ml,与非癫痫患儿血清中维生素B1和B12浓度[（130.44±5.12） nmol/L和（197.87±19.36） pg/ml]相比,差异无统计学意义（P=0.095,P=0.077）.癫痫患儿血清中维生素B6的浓度为（44.61 ±2.49） μmol/L,显著低于非癫痫患儿的血清维生素B6浓度（64.63±5.71） μmol/L （P=0.031）.结论 血清维生素B1、B12含量与癫痫无相关性,而血清维生素B6含量低下可能增加癫痫发作的风险.

Serum concentration of B vitamins and their correlation to epilepsy

Objective To investigate the correlation of serum concentration of B vitamins B1,B6,B12） with the incidence of epilepsy.Methods We recruited 50 newly diagnosed patients with epilepsy （not receiving antiepileptic drugs） and 50 patients without epilepsy.Serum concentrations of B vitamins （B1,B6,and B12） in both groups were detected with a LK3000V vitamin detector.Results The concentrations of vitamin B1 and B12 in epileptic patients were （132.81 ±7.3l） nmol/L and （221.41 ±26.09） pg/ml,respectively,not significantly different from those in non-epileptic patients [（130.44 ± 5.12） nmol/L,P =0.095 ;（197.87 ± 19.36） pg/ml,P =0.077].The concentration of vitamin B6 in epileptic children was （44.61 ±2.49） μmol/L,significantly lower than that in non-epileptic children [（64.63 ± 5.71） μmol/L,P =0.031].Conclusion Though serum concentrations of vitamin B1 and B12 may not be associated with epilepsy,lower concentration of vitamin B6 in serum may increase the risk of epilepsy.