氟哌噻吨美利曲辛治疗原发性高血压合并焦虑抑郁患者疗效观察

目的探讨小剂量氟哌噻吨美利曲辛治疗原发性高血压合并焦虑抑郁患者的临床疗效及生活质量改变。方法选取抑郁自评量表和焦虑自评量表评分均为阳性的100例原发性高血压合并焦虑抑郁的患者,分为对照组和观察组,每组50例。对照组患者给予常规治疗;观察组患者在对照组治疗的基础上给予小剂量氟哌噻吨美利曲辛治疗,随访8周。比较2组患者治疗后平均血压下降值、降压治疗有效率及生活质量评分改变。结果观察组患者收缩压和舒张压平均下降程度、降压治疗有效率均高于对照组,差异有统计学意义(P<0.05)。观察组患者生存质量改善明显优于对照组,差异有统计学意义(P<0.01)。结论小剂量氟哌噻吨美利曲辛治疗原发性高血压合并焦虑抑郁患者可明显提高降压疗效,改善患者生活质量。

Effectiveness of flupentixol melitracen on treatment for primary hypertension patients with anxiety and depression

Objective To study the efficacy of small doses of flupentixol melitracen on treatment for hypertensive patients with anxiety and depression and the life quality changes of them. Methods One hundred primary hypertension patients, whose scores of self-rating depressive scale and self-rating anxiety scale were positive,were divided into control group and observation group,with 50 cases in each group. The control group was given routine treatment,while the observation group was given small doses of flupentixol melitracen combined with conventional treatment. All the patients were followed up for 8 weeks. The average blood pressure decreasing level,efficient rate of blood pressure decreasing and life quality evaluation were compared between the two groups after treatment. Results After treatment,the average systolic pressure and diastolic pressure decreasing level and efficient rate of blood pressure decreasing in observation group were higher than those in control group,the differences were significant（ P 0. 05）. The quality of life was improved more significantly in observation group than that in the control group（ P 0. 01）. Conclusion Small dose of flupentixol melitracen to treat primary hypertension patients with anxiety and depression can improve the curative effect and quality of life obviously.