| 高脂饮食联合链脲佐菌素建立2型糖尿病大鼠模型的研究进展 |
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| 引用本文： | 邵俊伟,蔡逊. 高脂饮食联合链脲佐菌素建立2型糖尿病大鼠模型的研究进展[J]. 实验动物与比较医学, 2014, 22(4): 90-93 |
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| 作者姓名： | 邵俊伟 蔡逊 |
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| 作者单位： | 广州军区武汉总医院普通外科, 武汉 430070;广州军区武汉总医院普通外科, 武汉 430070 |
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| 基金项目： | 湖北省自然科学基金（编号：2010CDB09201）。 |
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| 摘 要： | 2型糖尿病大鼠模型的建立能够为糖尿病及其并发症的发病机制、预防、诊断及治疗的研究提供理想的动物实验技术平台。2型糖尿病大鼠模型的成模率受多种因素的影响,本文就建立2型糖尿病大鼠模型的主要影响因素STZ的应用、高脂高糖饮食及大鼠的选择与饲养等做一综述。以期对建立2型糖尿病大鼠模型的方法提供一定的参考价值。
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| 关 键 词： | 2型糖尿病 大鼠模型 链脲佐菌素 高脂饮食 |
| 收稿时间： | 2014-01-27 |
Research progress of rat models of type 2 diabetes induced by high calorie diet combined with streptozotocin |
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| SHAO Jun-wei and CAI Xun. Research progress of rat models of type 2 diabetes induced by high calorie diet combined with streptozotocin[J]. Laboratory Animal and Comparative Medicine, 2014, 22(4): 90-93 |
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| Authors: | SHAO Jun-wei and CAI Xun |
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| Affiliation: | Department of General Surgery, Wuhan General Hospital of Guangzhou Military Command of PLA, Wuhan 430070, China;Department of General Surgery, Wuhan General Hospital of Guangzhou Military Command of PLA, Wuhan 430070, China |
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| Abstract: | The establishment of rat models of type 2 diabetes mellitus can provide an ideal animal experimental technology platform for the research of pathogenesis, prevention, diagnosis and treatment of diabetes mellitus and its complications. The establishment of type 2 diabetic rat models may be affected by various factors. In this paper, the main factors, streptozotocin (STZ) application, high fat and calorie diet, selection and breeding of rats are reviewed, which will provide an important reference for the development of rat models type 2 diabetes. |
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| Keywords: | Type 2 diabetes mellitus Rat, model Streptozotocin High fat and calorie diet |
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