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Secondary nonresponsiveness to botulinum toxin type A in patients with oromandibular dystonia.
Authors:Charles H Adler  Stewart A Factor  Mitchell Brin  Kapil D Sethi
Affiliation:Parkinson's Disease and Movement Disorders Center, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA. cadler@mayo.edu
Abstract:
Intramuscular injection of botulinum toxin type A is the treatment of choice for most cases of oromandibular dystonia. We report on five patients with oromandibular dystonia that developed secondary nonresponsiveness to botulinum toxin type A following multiple injections over a 6-year period.
Keywords:oromandibular dystonia  botulinum toxin  immunoresistance
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