血栓弹力图监测下的阿司匹林抵抗对急性脑梗死患者神经功能恢复的影响

目的 通过血栓弹力图（TEG）识别阿司匹林抵抗与阿司匹林敏感,探讨阿司匹林抵抗对急性脑梗死患者神经功能恢复情况的影响.方法 选取109例急性脑梗死患者,根据血栓弹力图结果将其分为阿司匹林抵抗组和阿司匹林敏感组,评价其90天的神经功能恢复情况.同时对所有服用阿司匹林的患者进行相关危险因素分析.结果 阿司匹林敏感者与阿司匹林抵抗者比较,治疗90天神经功能恢复情况明显较好,差异有统计学意义（P＜0.05）.血小板计数、常规凝血与TEG结果有较好的一致性.糖尿病与阿司匹林抵抗有关（P＜0.01）.结论 对于急性脑梗死患者,阿司匹林抵抗与其神经功能恢复有关,血栓弹力图有助于评价患者是否存在阿司匹林抵抗.

The recovery of neurological function of aspirin resistance in patient with acute cerebral infarction detected by thrombelastography

Objective To divide aspirin resistance or aspirin sensitive by thrombelastography （TEG）,investigate the understanding of aspirin resistance in patients with acute cerebral infarction affecting the recovery of neurological function.Methods The 109 cases of acute cerebral infarction was divided into groups of aspirin resistance and aspirin sensitive group according to the TEG results.Infarction of them followed 90 days.evaluation of its recovery of neurological function.Meanwhile,all the cases were related risk factor analysis.Results Those who aspirin sensitive had better recovery of neurological function than aspirin resistance ones after cure 90 days,their differences were statistically significant （P 〈 0.05）.Platelet count and routine coagulation were in good agreement with TEG results.Diabetes was related with aspirin resistance（P 〈0.01）.Conclusion Neurological recovery is related with aspirin resistance in patients with acute cerebral infarction.TEG can help in evaluating with aspirin resistance exists.