维持性血液透析病人不宁腿综合征现状的调查研究

目的]了解维持性血液透析病人不宁腿综合征(RLS)现状,为透析病人RLS干预提供依据。方法]采用回顾性研究对华中科技大学同济医学院附属同济医院的维持性血液透析病人135例进行RLS现状调查。RLS诊断标准是按照国际不宁腿综合征研究小组(IRL-SSG)的诊断标准进行诊断。结果]维持性血液透析病人中RLS的患病率为18.5%(n=25);单因素分析表明,维持性血液透析RLS病人与非RLS病人在性别、高血压、皮肤瘙痒、透析时间、血清镁、血清铁、甲状旁腺素、血清磷等人口学和临床指标比较差异有统计学意义(P<0.05)。多因素Logistic回归模型显示,4个独立影响因素与维持性血液透析病人RLS的发生显著相关,分别为每日饮酒(OR=2.832,95%CI=2.023~3.378),血清铁(OR=1.560,95%CI=1.274~1.740),血清镁(OR=1.927,95%CI=1.792~2.219),女性(OR=1.307,95%CI=1.187~1.534)。结论]每日饮酒、血清镁、血清铁、女性是维持性血液透析病人RLS的影响因素。因此,临床工作者应针对相关因素制定相关干预措施,降低维持性血液透析病人RLS发生率,提高维持性血液透析病人生活质量。

Investigation and research on the status quo of restless legs syndrome in patients undergoing maintenance hemodialysis

Objective:To understand the status quo of restless legs syndrome(RLS)in patients undergoing maintenance hemodialysis,and to provide the evidence for the intervention of RLS in patients undergoing maintenance hemodialysis.Methods:A retrospective study was conducted on the status quo of RLS in 135 patients undergoing maintenance hemodialysis in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.The diagnostic criteria of RLS are based on the diagnostic criteria of the International Restless Leg Syndrome Study Group(IRL-SSG).Results:The prevalence of RLS in patients undergoing maintenance hemodialysis was 18.5%(n=25).The univariate analysis showed that there were significantly differences in gender and hypertension,skin itching,dialysis time,and levels of serum magnesium,serum iron,parathyroid hormone,and serum phosphorus between RLS patients and non-RLS patients undergoing maintenance hemodialysis(P<0.05).The multivariate logistic regression model showed that four independent factors were significantly associated with the occurrence of RLS in patients undergoing maintenance hemodialysis.RLS was significantly associated with daily drinking(OR=2.832,95%CI:2.023-3.378)and serum iron(OR=1.560,95%CI:1.274-1.74),serum magnesium(OR=1.927,95%CI:1.792-2.219),female(OR=1.307,95%CI:1.187-1.534).Conclusion:The daily drinking,serum magnesium,serum iron,and female are the influencing factors of RLS in patients undergoing maintenance hemodialysis.Therefore,clinicians should formulate relevant intervention for relevant factors,reduce the incidence of RLS,and improve the quality of life in patients undergoing maintenance hemodialysis.