急性精神分裂症神经内分泌激发试验研究

目的:研究急性精神分裂症患者中枢五羟色胺(5-HT)的功能状态及其临床意义。方法:对27例急性精神分裂症进行神经内 分泌激发试验,以催乳素作为应答指标,对临床症状采用阳性和阴性综合征量表进行评定。结果:催乳素基础水平与健康对照组无 显著差异(P>0.05)。激发后的催乳素水平呈增高趋势,且幅度趋于明显,与对照组比较,存在显著差异(P<0.05,P<0.01)。催 乳素基础水平、激发反应值以及曲线下面积与PANSS量表因子及总分之间均未发现明显的相关关系(P>0.05)。结论:急性精神 分裂症患者中枢五羟色胺的功能可能更加亢进,但与精神症状之间元明显相关性。

Significance of Neuroendocrine Provocative Test in Management of Acute Schizophrenia Episode

Objective: To investigate the functional state of 5-hydroxytryyamine (5-HT) and its clinical significance in acute schizophrenia episode. Methods: 30 cases of acute schizophrenia episode underwent neuroendocrine provocative test and prolactin (PRL) level was determined as the reponse indicator The clinic symptoms were evaluated by The Positive and Negative Syndrome Scale (PANSS). Results:The basic prolactin level was not significantly different in the patients from that in controls (P > 0. 05). The paroxetine-stimulated PRL level tended to increase and the difference between the patients and normal controls was getting increasingly greater (P<0. 05 ,P <0. 01). The basic and stimulated levels of PRL,and the dimention under the curve were not significantly correlated with each individual factor and the total points in PANSS. Conclusions:The central 5-HT might be more hyperfunctional in acute schizophrenia episode, but it was not significantly correlated with mental symptoms.