长托宁联合N6环戊基腺苷救治急性有机磷农药中毒临床观察

目的:探讨长托宁联合应用N6环戊基腺苷(CPA)治疗急性有机磷农药中毒(AOPP)的临床疗效。方法:将40例中、重度AOPP患者随机分为治疗组和对照组(各20例),长托宁联合CPA救治患者为治疗组;单用长托宁救治患者为对照组。分析比较2组长托宁首次量、追加量、用药总量、胆碱脂酶(CHE)上升时间、达长托宁化时间、长托宁不良反应发生率。结果:治疗组长托宁首次用药量、追加量及用药总量比对照组明显减少(均P0.05),长托宁不良反应发生率明显低于对照组(P0.05),"长托宁化"时间及"CHE上升"时间明显短于对照组(P0.05)。结论:长托宁联合CPA治救AOPP,能合理减少长托宁用量,迅速达到或维持"长托宁化",显著减少长托宁不良反应发生率。

Clinical observation on penehyclidine hydrochloride combined with N6 cyclopentyl adenosine in rescue of acute organophosphorus pesticide poisoning

Objective ： To explore the clinical therapeutic effect of penehyclidine hydrochloride combined with N6 cyclopentyl adenosine （CPA） in treatment of acute organophosphorus pesticide poisoning （AOPP）. Methods： Forty Patients with severe and moderate AOPP were randomly divided into treatment group and control group （20 cases for each group）. Patients in treatment group received penehyclidine hydrochloride combined with CPA, while those in control group received penehyclidine hydrochloride only. The initial dose of penehyclidine hydrochloride, the additional dosage and the total dosage of penehyclidine hydrochloride, the time required for increase of CHE, hydrochloride penehyclidine ether time, the frequency of adverse reactions of penehyclidine hydrochloride were compared. Results： The initial dose of penehyclidine hydrochlofide, the additional dosage of penehyclidine hydroehloride, the total dosage were less in treatment group than those in control group （P 〈 0.05 ）. The frequency of adverse reactions of penehyclidine hydrochloride was significantly less than that in control group （ P 〈 0.05 ）. ＂hydrochloride penehyclidine ether＂ time and＂ CHE rose ＂time were significantly shorter than those of control group （P 〈 0.05 ）. Conclusions ： Penehyclidine hydrochloride combined with CAP in rescuing AOPP, can reasonably reduce the dosage of penehyclidine hydrochloride used, more feasible to achieve or maintain ＂hydrochloride penehyclidine ether＂, thus effectively reduce the occurence of adverse reactions of penehyclidine hydrochloride.