长期吸毒者脑FDG-PET表现

目的:使用PET观察长期吸毒者脑代谢变化,为研究吸毒者神经生理和行为改变以及吸毒治疗提供分子影像学资料。方法:对比吸食海洛因时间均超过10年的吸毒者7例与健康体检者11例的脑FDG-PET检查资料并导入PC机,通过自行研发的软件进行图像配准,在配准后的横断层图像上画左侧脑结构感兴趣区(ROI):顶叶、扣带前回、丘脑、尾状核头、纹状体、眶上回、直回、颞叶外侧皮质、海马、小脑皮质,再镜像生成对侧相应脑结构的ROI,每个脑结构画相邻两个层面的ROI,取两个ROI平均放射性计数的算术均数为该脑结构的平均放射性计数,将各脑结构与同侧小脑皮质平均放射性计数相比。结果:吸毒者全脑葡萄糖代谢均减低,有统计学意义的部位为双侧尾状核头、双侧纹状体、双侧眶上回、双侧直回和双侧颞叶外侧皮质(t<0.05)。结论:PET可探测吸毒者脑代谢的变化,为研究吸毒者神经生理、病理和行为改变以及吸毒治疗、预后评价提供分子影像学资料。

Cerebral Metabolism Imaging in Long-term Drug Abuser with FDG-PET

Objective: To observe the change of cerebral metabolism in long-term drug abuser by positron emission tomography(PET) with 2-deoxy-2[18F]fluoro-D-glucose (18FDG), and to provide the information of molecular imaging for the study of drug addiction. Methods: 7 cocaine-dependent subjects with cocaine addicted history of more than 10 years and 11 comparison subjects were involved in the study. After PET scan the data of the subjects were transmitted to computer, image registration was performed by the self-developed software according to the standard MRI brain imaging. Then regions of interest(ROIs) were drawn in left cerebral structures which include parietal cortex, anterior cingulate gyrus, head of caudate nucleus, striaturn, thalamus, inferior frontal gyrus, orbitofrontal cortex, exterior temporal cortex (including insular lobe), hippocampum and cerebellar cortex, antimere of each brain structure was created enantiomorphously. Two ROIs of each structure were drawn in the adjoining imaging slices. Mean radioactive counts of ROIs were calculated by the software. Analysis was used to compare the ROIs of each brain structures with these of the iso-lateral cerebellar cortex respectively. Results: Long-term drug addicted subjects showed reduction of cerebral metabolic rate of glucose of brain structures in some extent except for right parietal cortex. Conclusion: PET imaging can be used for the study of drug abuse.