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| 受体三阴性乳腺癌中CK14和EGFR的检测及临床意义 | |
| 引用本文： | 赵鸿,薛娣,冷冬妮. 受体三阴性乳腺癌中CK14和EGFR的检测及临床意义[J]. 医疗保健器具, 2011, 18(6): 862-863. DOI: 10.3936/j.issn.1674-4659.2011.06.0862 |
| 作者姓名： | 赵鸿 薛娣 冷冬妮 |
| 作者单位： | 1. 南京医科大学第一附属医院检验科,江苏,南京,210029 2. 江苏省镇江市第一人民医院病理科,江苏,镇江,212002 3. 解放军第454医院病理科,江苏,南京,210002 |
| 摘 要： | 目的研究三阴性乳腺癌中CK14和EGFR蛋白的表达及意义。方法免疫组化法检测95例三阴性及50例非三阴性浸润性乳腺癌中CK14和EGFR蛋白的表达,运用荧光原位杂交（FISH）检测4例EGFR基因扩增情况。结果所有三阴性乳腺癌病例显示为高级别癌,核分裂像易见。肿瘤组织具有推进式的边缘,周围伴淋巴细胞浸润。瘤细胞呈合体细胞样,通常见坏死。免疫组化示ER、PR和HER2均阴性,CK14和EGFR在三阴性乳腺癌中的表达率分别为83.2%和65.3%,在非三阴性乳腺癌中的表达率分别为2.0%和20.0%（P〈0.01）。4例FISH检测见EGFR基因扩增。结论三阴性乳腺癌具有独特的组织学与基底样细胞表型,EGFR常过度表达,对于EGFR分子靶向治疗可能有效。 |
| 关 键 词： | 三阴性乳腺癌 免疫组化 FISH CK14 EGFR |
Detection of CK14 and EGFR in Triple-negative Breast Carcinoma and Its Clinical Significance |
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| ZHAO Hong,XUE Di,LENG Dongni. Detection of CK14 and EGFR in Triple-negative Breast Carcinoma and Its Clinical Significance[J]. Medicine Healthcare Apparatus, 2011, 18(6): 862-863. DOI: 10.3936/j.issn.1674-4659.2011.06.0862 | |
| Authors: | ZHAO Hong XUE Di LENG Dongni |
| Affiliation: | ZHAO Hong 1,XUE Di 2,LENG Dongni 3(1Department of Clinical Laboratory,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China,2Department of Pathology,the First People's Hospital of Zhenjiang,Zhenjiang 212002,3Department of Pathology,454 Hospital of PLA,Nanjing 210002,China) |
| Abstract: | Objective To investigate the expression of CK14,EGFR in triple-negative invasive breast carcinoma and its significance. Methods 95 cases of triple-negative tumours and 50 cases of non-triple-negative tumours were tested by immunohistochemical method. EGFR gene in 4 cases were tested by fluorescence in situ hybridization(FISH) . Results All triple-negative invasive breast carcinoma were high grade with a very high mitotic index,the tumors had pushing margins with a peri-tumoural lymphocytic infiltrate and ha... |
| Keywords: | FISH CK14 EGFR |
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