| 减毒的沙门氏菌在肿瘤基因治疗中的研究进展 |
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| 引用本文： | 赵丽华,李妍涵,韩忠朝. 减毒的沙门氏菌在肿瘤基因治疗中的研究进展[J]. 医学分子生物学杂志, 2004, 1(1): 55-57 |
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| 作者姓名： | 赵丽华 李妍涵 韩忠朝 |
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| 作者单位： | 中国医学科学院中国协和医科大学血液学研究所,天津市,300020;中国医学科学院中国协和医科大学血液学研究所,天津市,300020;中国医学科学院中国协和医科大学血液学研究所,天津市,300020 |
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| 摘 要： | 减毒的沙门氏菌是一种非病原性细菌,能靶向肿瘤并产生局部抗肿瘤的效应。减毒的沙门氏菌能选择性地在肿瘤组织中复制,表达编码治疗性蛋白的效应基因是肿瘤基因治疗有应用前景的一种途径,这种方式也将成为目前实体瘤放疗、化疗的一种辅助的治疗方法。
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| 关 键 词： | 沙门氏菌 肿瘤 基因治疗 |
| 修稿时间： | 2003-10-22 |
The Advances in the Study of Attenuated Salmonella in Tumor Gene Therapy |
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| ZHAO Lihua,LI Yanhan,HAN ZhongchaoChinese Academy of Medical Sciences,Peking Union Medical College. The Advances in the Study of Attenuated Salmonella in Tumor Gene Therapy[J]. Journal of Medical Molecular Biology, 2004, 1(1): 55-57 |
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| Authors: | ZHAO Lihua LI Yanhan HAN ZhongchaoChinese Academy of Medical Sciences Peking Union Medical College |
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| Affiliation: | ZHAO Lihua,LI Yanhan,HAN ZhongchaoChinese Academy of Medical Sciences,Peking Union Medical College,Institute of Hematology,Tian-jin,300020,China |
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| Abstract: | Attenuated salmonella is a group of non-pathogenic bacteria that can target tumors and has local anti-tumor effects. In this review, we described an alternative gene delivery system on the basis of attenuated salmonella. Attenuated salmonella strains capable of both selective amplification within tumors and expression of effect genes encoding therapeutic proteins are probably the most promising way in gene therapy of tumors. We believe that this approach will serve as a complement to the current radio-therapeutic and chemo-therapeutic treatments of solid tumors. |
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| Keywords: | salmonella tumor gene therapy |
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