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| 链阳性菌素衍生物的半合成及构效关系 | |
| 引用本文： | 金志华,吴亚铭,岑沛霖. 链阳性菌素衍生物的半合成及构效关系[J]. 中国现代应用药学, 2000, 17(4): 297-301 |
| 作者姓名： | 金志华 吴亚铭 岑沛霖 |
| 作者单位： | 1. 杭州,310027,浙江大学化工学院生物化工系 2. 新昌,312500,浙江医药股份有限公司新昌制药厂 |
| 摘 要： | 目的：介绍链阳性菌系半合成修饰的研究进展。方法：总结链阳性菌素衍生物的半合成及构效关系。结果和结论：原始霉素两主组分的半合成修饰产生了新的水溶性原始霉素衍生物，这些衍生物具有与天然产物相同的所有生物学特性，并能通过静脉给药。新的水溶性复合剂ＲＰ５９５００具有治疗由革兰氏阳性菌引起的严重感染所需的特性。 |
| 关 键 词： | 链阳性菌素衍生物 半合成 构效关系 RP59500 |
Semisynthesis and structure-activity relationships of streptogramin derivatives |
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| Jin Zhihua(Jin ZH,Wu Yaming(Wu YM,Cen Peilin(Cen PL. Semisynthesis and structure-activity relationships of streptogramin derivatives[J]. The Chinese Journal of Modern Applied Pharmacy, 2000, 17(4): 297-301 | |
| Authors: | Jin Zhihua(Jin ZH Wu Yaming(Wu YM Cen Peilin(Cen PL |
| Abstract: | OBJECTIVE:To review advances of semisynthetic modifications of streptogramins.METHODS:To summarize methods of semisynthesis and the relationships of structureactivity of streptogramin derivatives.RESULTS and CONCLUSIONS:With semisynthetic modifications of the major components of pristinamycins,novel watersoluble pristinamycin derivatives,which retains all the biological properties of the natural products and can be administered by the intravenous route, were obtained.The new watersoluble complex,RP59500,is of the properties required for the treatment of severe infections caused by Grampositive bacteria. |
| Keywords: | streptogramin semisynthesis structure-activity relationships RP59500 |
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