依达拉奉与依帕司他序贯治疗糖尿病周围神经病变的疗效观察

目的：观察依达拉奉与依帕司他序贯治疗糖尿病周围神经病变的疗效。方法：选取糖尿病周围神经病变患者120例,以随机抽样法分为2组,在常规调整血糖到较满意水平基础上,治疗组予以依达拉奉与依帕司他序贯治疗,对照组单用依达拉奉治疗,2组均治疗8周。结果：治疗组与对照组神经病变主觉症状问卷（TSS）评分分别为（3.76±1.25）、（7.94±1.30）分,2组比较,差异有统计学意义（P〈0.01）。结论：依帕司他联合依达拉奉长期合理应用可减少糖尿病患者的氧化应激,有效遏制糖尿病周围神经病变的发生。

Efficacy of Edaravone and Epalrestat Sequential Therapy for Diabetic Peripheral Neuropathy

OBJECTIVE：To evaluate the curative efficacy of epalrestat and edaravone sequential therapy for diabetic peripheral neuropathy.METHODS： 120 patients with diabetic peripheral neuropathy were randomly assigned to two groups treated with epalrestat plus edaravone by sequential therapy（treatment group） or edaravone alone（control group） for 8 weeks in addition to conventional adjusting blood sugar to satisfactory level.RESULTS： The total symptoms score（TSS） in the treatment group and the control group were 3.76±1.25 and 7.94±1.30,respectively,showing significant differences between the two groups（P0.01）.CONCLUSION： Long-term use of epalrestat in combination with edaravone can reduce oxidative stress in diabetetic patients and effectively prevent diabetic peripheral neuropathy.