复方雷公藤治疗慢性肾炎的研究

为了探讨雷公藤对慢性肾炎的疗效及其机理,本文用复方雷公藤治疗家兔实验性慢性肾炎及慢性肾炎病人。未治疗组兔尿蛋白“十～(?)”;血肌酐及尿素氮升高;肾小球呈现中至重度颗粒形荧光;显微分光光度计检测显示肾小球有较强的IgG免疫荧光;光镜下兔肾组织呈明显慢性硬化性肾小球肾炎改变;电镜下肾小球毛细血管基底膜上可见电子致密物沉积,足突变平坦、融合。治疗组免上述病变及症状均明显减轻到消的。临床治疗肾炎患者尿蛋白明显减轻到消失,总有效率90.24％。结果表明:复方雷公藤对慢性肾炎病变的发生发展有一定的控制作用,对减轻和消除尿蛋白有明显疗效,并可降低血肌酐及尿素氮,这可能是雷公藤对特异性抗体的产生及免疫复合物形成有抑制作用的结果。

A Study of Chronic Glomerulonephritis Treated with Composite Tripterygium Wilfordii

In order to assess the effect of Tripterygium Wilfordii on chronic glomerulonephritis and its mechanism, the authors treated rabbits and patients suffered from chronic glomerulonephritis with composite Tripterygium Wilfordii. In the untreated rabbits, the quantity of uninary protein was between "+-++"; the creatinine and urea nitrogen of blood serum increased; and moderate to severe IgG granular deposite appeared in glomeruli. Microspectrophotometer detection showed more irtensive immunofluorescence. The kidneys showed marked pathological changes of chronic sclerotic glomerulonephritis under a light microscope. Electron dense deposits in varying degrees, flattened and fused foot processes and irregularly thickened basement membrane were demonstrated by an electron microscope. In the treated rabbits, all pathological changes and symptoms obviously abated or disappeared. The effect of clinical treatment showed that the urinary protein is markedly diminished or absent, with a total cure rate being 90.24 %. The experimental results suggest that the composite Tripterygium Wilfordii might inhibit production of the antibodies and formation of immune complex.