白细胞介素18与心绞痛患者左室射血分数的相关性研究

测定不稳定心绞痛(UA)和稳定心绞痛(SA)患者外周静脉血中白细胞介素18(IL-18)的浓度，观察其与心绞痛患者左室射血分数的相关性。选择2002年12月至2004年1月间住院患者80例，其中UA组40例。SA组20例，对照组20例，均行冠状动脉造影和超声心动图检查，采用酶联免疫吸附法(ELISA)测定外周血清IL-18水平。结果发现，与对照组相比，UA组和SA组IL-18浓度明显增高，LVEF＜50％的心绞痛患者IL-18浓度显著高于LVEF＞50％的冠心病患者，但UA组与SA组之间差异无统计学意义。结果提示，白细胞介素18和冠状动脉病变正相关，但对动脉粥样硬化斑块的稳定性无预测价值，而与心功能状态负相关。IL-18在心绞痛的预后判定中有重要价值。

The research of correlation of Interleukin-18 with angina pectoris patients''''Left ventricular ejection fraction

Aim To detect the peripheral venous blood' concentration of IL-18 in patients with UA and SA and evaluate it's correlation with angina pectoris patients'left ventricular ejection fraction. Methods Eighty hosipitalized patients were enrolled in this research since 2002.12 to 2004.01. Forty cases were UA, twenty cases were SA,twenty cases were normal controls.All patients were performed coronary artery angiography and Doppler echocardiography. IL-18 was measured with ELISA methods. Results The concentrations of IL-18 in UA and SA were much higher than controls', but there were no difference between these two. Patients with LVEF<50% had higher IL-18 concentrations than those with LVEF>%. Conclusion IL-18 was positive correlated to coronary artery diseases, but no prodiction to the stability of AS plaques. And it was nagtive correlated to Left ventricular ejection fraction(LVEF). So IL-18 had important values in prodiction of angina pectoris.