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| 枳实对脑梗死大鼠急性期胃黏膜的保护性作用 | |
| 引用本文： | 唐明,安朋朋,任志珍,唐晓晓,仇莎,司增顺.枳实对脑梗死大鼠急性期胃黏膜的保护性作用[J].中西医结合心脑血管病杂志,2014(10):1255-1256. |
| 作者姓名： | 唐明 安朋朋 任志珍 唐晓晓 仇莎 司增顺 |
| 作者单位： | 1. 山东省青岛市海慈医疗集团 266033 2. 山东省青岛市南区社区卫生服务中心 266000 3. 山东省青岛市开发区第一人民医院 266555 4. 山东中医药大学 250014 |
| 基金项目： | 山东省中医药科技发展计划项目 |
| 摘 要： | 目的：观察脑梗死大鼠急性期胃黏膜损害性的变化，研究枳实对脑梗死急性期大鼠胃黏膜的保护性作用。方法采用线栓法制备大脑中动脉闭塞局灶性脑缺血大鼠模型，将所有大鼠分为正常对照组、假手术组、脑梗死组、西咪替丁组、枳实组，连续灌胃4 d后处死大鼠，分离胃组织进行电镜观察。结果与正常对照组及假手术组相比，脑梗死大鼠的胃黏膜结构出现明显的组织破坏，枳实组与西咪替丁均能减轻上述组织破坏，且枳实的疗效优于西咪替丁。结论脑梗死急性期胃黏膜出现明显损害，枳实对急性脑梗死导致的胃黏膜损害具有一定的保护性作用。 |
| 关 键 词： | 脑梗死 枳实 胃黏膜 电镜 大鼠 |
The P ro tective Effect of C itrus Aurantium on G astric T issue in the Acute S tage of C erebral Infarction |
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| Institution: | Tang Ming,An Pengpeng,Ren Zhizhen,et al(Haici Medical Center of Qingdao,Shandong(Qingdao 266033)) |
| Abstract: | O bjective To observe the injured biliary changes o f gastric m ucosal lesions in the acute stage of cerebral infarction rats ,and to study the pro tective effect o f C itrus Aurantium on gastric tissue .M ethods The focal cerebral ischem ia rats m odelw ere induced by intralum inalm iddle cerebral artery occlusion.A l rats w ere random ly divided into 5 g roups ：Norm al contro l group ,sham operated group cerebral Infarction group ,cim etidine group and C itrus Aurantium group .A l rats w ere kiled after gavage once a day for 4 days .Then the gastric m ucosa o f these anim als w ere exam ined w ith scanning electron m icroscope .Results Com pared w ith no rm al contro lgroup and sham operated g roup ,patho log ical changes in gastric m ucosa w ere found.C itrus Aurantium group and ci-m etidine could am eliorate the gastricm ucosal lesions ,and the curative effects ofC itrus Aurantium w ere m uch better than those of ci-m etidine .Conclusion G astric m ucosa injury appeared after cerebral infarction.C itrus Aurantium has the certain pro tective effect for cerebral infarction. |
| Keywords: | cerebral infarction citrus aurantium gastric m ucosa electron m icroscope rat |
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