中药天癸方治疗多囊卵巢综合征中高雄激素高胰岛素血症 …

目的：探讨中药天癸方治疗多囊卵巢综合征（ＰＣＯＳ）中高雄 激素高胰岛素血症的疗效及作用机理。方法：观察２２例克罗米芬治疗无效的ＰＣＯＳ患者应用天癸方（１０例）和二甲双胍（１２例）治疗３个月前后血黄体生成素（ＬＨ）、卵泡刺激素（ＦＳＨ）、血睾酮（Ｔ）、雌二醇（Ｅ２）浓度和口服糖耐量试验（ＯＧＴＴ）试验中血胰岛素（Ｉｎｓ）浓度,腰臀比值（ＷＨＲ）、体重指数（ＢＭＩ）的变化。结果：服用“天癸方”患者血Ｉ

Studyon Treatment of Hyperandrogenism and Hyperinsulinism in Polycystic Ovary Syndrome withChinese Herbal Formula

OBJECTIVE: To observe the efficacy of Chinese herbal formula "Tiangui Fang" (TGF) in hyperandrogenism and hyperinsulinism patients of polycystic ovarian syndrome (PCOS), and compare with western medicine metformin. METHODS: Twenty-two anti-clomiphen citrite patients were divided into two treatment groups: "Tiangui Fang" (n = 10) and metformin (n = 12) for three months. Insulin response during oral glucose tolerance test and serum level of LH, FSH, testosterone (T), estradiol (E2) and waist to hip ratio (WHR), body mass index (BMI) were measured before and after treatment. RESULTS: After treatment for three months with metformin or TGF, fasting and the integrated insulin response to the glucose load decreased. Treated by metformin 4 out of 8 patients had restoration of menstrual cyclicity and 2 of them had double phase bases body temperature (BBT). This was accompanied by lowering in serum logT/E2 but had no significant difference, the BMI, WHR and serum E2, LH:FSH ratio were not changed. Treated by TGF for three months, 6 out of 8 patients had restoration of menstrual cyclicity and double phase BBT. This was accompanied by significant lowering in serum T, logT/E2 and BMI (P < 0.05), serum LH:FSH ratio were not changed. CONCLUSION: Both metformin and TGF can reduce the high concentration of insulin in PCOS patients and induce ovulation, the herbal formula has a better efficacy.